Probing the Relationship between Anti-Pneumocystis carinii Activity and DNA Binding of Bisamidines by Molecular Dynamics Simulations

The anti-Pneumocystis carinii activity of 13 synthetic pentamidine analogs was analyzed. The experimental differences in melting points of DNA dodecamer 5'-(CGCGAATTCGCG)(2)-3' complexes (ΔT(m)), and in the biological activity measured using ATP bioluminescence assay (IC(50)) together with...

Descripción completa

Detalles Bibliográficos
Autores principales: Żołek, Teresa, Maciejewska, Dorota, Żabiński, Jerzy, Kaźmierczak, Paweł, Rezler, Mateusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272165/
https://www.ncbi.nlm.nih.gov/pubmed/25854757
http://dx.doi.org/10.3390/molecules20045942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272165/
https://www.ncbi.nlm.nih.gov/pubmed/25854757
http://dx.doi.org/10.3390/molecules20045942

Ejemplares similares