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Probing the Relationship between Anti-Pneumocystis carinii Activity and DNA Binding of Bisamidines by Molecular Dynamics Simulations
The anti-Pneumocystis carinii activity of 13 synthetic pentamidine analogs was analyzed. The experimental differences in melting points of DNA dodecamer 5'-(CGCGAATTCGCG)(2)-3' complexes (ΔT(m)), and in the biological activity measured using ATP bioluminescence assay (IC(50)) together with...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272165/ https://www.ncbi.nlm.nih.gov/pubmed/25854757 http://dx.doi.org/10.3390/molecules20045942 |