Synthesis and Pharmacophore Modelling of 2,6,9-Trisubstituted Purine Derivatives and Their Potential Role as Apoptosis-Inducing Agents in Cancer Cell Lines

A series of 2,6,9-trisubstituted purine derivatives have been synthesized and investigated for their potential role as antitumor agents. Twelve compounds were obtained by a three step synthetic procedure using microwave irradiation in a pivotal step. All compounds were evaluated in vitro to determin...

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Detalles Bibliográficos
Autores principales: Calderón-Arancibia, Jeannette, Espinosa-Bustos, Christian, Cañete-Molina, Álvaro, Tapia, Ricardo A., Faúndez, Mario, Torres, Maria Jose, Aguirre, Adam, Paulino, Margot, Salas, Cristian O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272238/
https://www.ncbi.nlm.nih.gov/pubmed/25884555
http://dx.doi.org/10.3390/molecules20046808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272238/
https://www.ncbi.nlm.nih.gov/pubmed/25884555
http://dx.doi.org/10.3390/molecules20046808

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