Combined Pharmacophore Modeling, 3D-QSAR, Homology Modeling and Docking Studies on CYP11B1 Inhibitors

The mitochondrial cytochrome P450 enzymes inhibitor steroid 11β-hydroxylase (CYP11B1) can decrease the production of cortisol. Therefore, these inhibitors have an effect in the treatment of Cushing’s syndrome. A pharmacophore model generated by Genetic Algorithm with Linear Assignment for Hypermolec...

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Detalles Bibliográficos
Autores principales: Yu, Rui, Wang, Juan, Wang, Rui, Lin, Yong, Hu, Yong, Wang, Yuanqiang, Shu, Mao, Lin, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272247/
https://www.ncbi.nlm.nih.gov/pubmed/25584832
http://dx.doi.org/10.3390/molecules20011014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272247/
https://www.ncbi.nlm.nih.gov/pubmed/25584832
http://dx.doi.org/10.3390/molecules20011014

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