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Combined Pharmacophore Modeling, 3D-QSAR, Homology Modeling and Docking Studies on CYP11B1 Inhibitors

The mitochondrial cytochrome P450 enzymes inhibitor steroid 11β-hydroxylase (CYP11B1) can decrease the production of cortisol. Therefore, these inhibitors have an effect in the treatment of Cushing’s syndrome. A pharmacophore model generated by Genetic Algorithm with Linear Assignment for Hypermolec...

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Detalles Bibliográficos
Autores principales:	Yu, Rui, Wang, Juan, Wang, Rui, Lin, Yong, Hu, Yong, Wang, Yuanqiang, Shu, Mao, Lin, Zhihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272247/ https://www.ncbi.nlm.nih.gov/pubmed/25584832 http://dx.doi.org/10.3390/molecules20011014

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