Kinase Inhibitor Profile for Human Nek1, Nek6, and Nek7 and Analysis of the Structural Basis for Inhibitor Specificity

Human Neks are a conserved protein kinase family related to cell cycle progression and cell division and are considered potential drug targets for the treatment of cancer and other pathologies. We screened the activation loop mutant kinases hNek1 and hNek2, wild-type hNek7, and five hNek6 variants i...

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Detalles Bibliográficos
Autores principales: Moraes, Eduardo Cruz, Meirelles, Gabriela Vaz, Honorato, Rodrigo Vargas, de Souza, Tatiana de Arruda Campos Brasil, de Souza, Edmarcia Elisa, Murakami, Mario Tyago, de Oliveira, Paulo Sergio Lopes, Kobarg, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272266/
https://www.ncbi.nlm.nih.gov/pubmed/25591119
http://dx.doi.org/10.3390/molecules20011176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272266/
https://www.ncbi.nlm.nih.gov/pubmed/25591119
http://dx.doi.org/10.3390/molecules20011176

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