Cargando…

Kinase Inhibitor Profile for Human Nek1, Nek6, and Nek7 and Analysis of the Structural Basis for Inhibitor Specificity

Human Neks are a conserved protein kinase family related to cell cycle progression and cell division and are considered potential drug targets for the treatment of cancer and other pathologies. We screened the activation loop mutant kinases hNek1 and hNek2, wild-type hNek7, and five hNek6 variants i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moraes, Eduardo Cruz, Meirelles, Gabriela Vaz, Honorato, Rodrigo Vargas, de Souza, Tatiana de Arruda Campos Brasil, de Souza, Edmarcia Elisa, Murakami, Mario Tyago, de Oliveira, Paulo Sergio Lopes, Kobarg, Jörg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272266/ https://www.ncbi.nlm.nih.gov/pubmed/25591119 http://dx.doi.org/10.3390/molecules20011176

Ejemplares similares

Characterization of the Human NEK7 Interactome Suggests Catalytic and Regulatory Properties Distinct from Those of NEK6
por: de Souza, Edmarcia Elisa, et al.
Publicado: (2014)

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing
por: Basei, Fernanda Luisa, et al.
Publicado: (2015)

NEK10 interactome and depletion reveal new roles in mitochondria
por: Peres de Oliveira, Andressa, et al.
Publicado: (2020)

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization
por: Haq, Tamanna, et al.
Publicado: (2015)

Checking NEKs: Overcoming a Bottleneck in Human Diseases
por: Peres de Oliveira, Andressa, et al.
Publicado: (2020)

Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain
por: Meirelles, Gabriela V, et al.
Publicado: (2011)

Expression of the NEK family in normal and cancer tissue: an immunohistochemical study
por: Melo-Hanchuk, Talita Diniz, et al.
Publicado: (2020)

NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin
por: Melo-Hanchuk, Talita D., et al.
Publicado: (2017)

Nek2 Kinase Signaling in Malaria, Bone, Immune and Kidney Disorders to Metastatic Cancers and Drug Resistance: Progress on Nek2 Inhibitor Development
por: Dana, Dibyendu, et al.
Publicado: (2022)

Mitotic Regulation by NEK Kinase Networks
por: Fry, Andrew M., et al.
Publicado: (2017)

Up to your NEK2 in CIN
por: Seachrist, Darcie D., et al.
Publicado: (2021)

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9
por: Richards, Mark W., et al.
Publicado: (2009)

Molecular modeling and docking of small molecule inhibitors against NEK2
por: Ramachandran, Balaji, et al.
Publicado: (2016)

Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6
por: De Donato, Marta, et al.
Publicado: (2018)

Physiological and Pathological Roles of Mammalian NEK7
por: Sun, Zhenzhen, et al.
Publicado: (2020)

NEK5 interacts with LonP1 and its kinase activity is essential for the regulation of mitochondrial functions and mtDNA maintenance
por: Ferezin, Camila de Castro, et al.
Publicado: (2021)

On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response
por: Pavan, Isadora Carolina Betim, et al.
Publicado: (2021)

Nek5: a new regulator of centrosome integrity
por: Prosser, Suzanna L., et al.
Publicado: (2015)

Fractionation-Dependent Radiosensitization by Molecular Targeting of Nek1
por: Freund, Isabel, et al.
Publicado: (2020)

2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase
por: Matheson, Christopher J., et al.
Publicado: (2020)

Identification of potent inhibitors of NEK7 protein using a comprehensive computational approach
por: Aziz, Mubashir, et al.
Publicado: (2022)

Identification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach
por: de Castro Ferezin, Camila, et al.
Publicado: (2022)

Structure–Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors
por: Elsocht, Mathias, et al.
Publicado: (2021)

NEK1 Phosphorylation of YAP Promotes Its Stabilization and Transcriptional Output
por: Khalil, Md Imtiaz, et al.
Publicado: (2020)

Use of a special Brazilian red-light emitting railroad worm Luciferase in bioassays of NEK7 protein Kinase and Creatine Kinase
por: Marina Perez, Arina, et al.
Publicado: (2017)

NEK1 Facilitates Cohesin Removal during Mammalian Spermatogenesis
por: Holloway, Kim, et al.
Publicado: (2011)

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase
por: Westwood, Isaac, et al.
Publicado: (2009)

Nek family of kinases in cell cycle, checkpoint control and cancer
por: Moniz, Larissa, et al.
Publicado: (2011)

Inhibition of Nek2 by Small Molecules Affects Proteasome Activity
por: Meng, Lingyao, et al.
Publicado: (2014)

NEK2 serves as a prognostic biomarker for hepatocellular carcinoma
por: Li, Gang, et al.
Publicado: (2017)

NEK7 is required for G1 progression and procentriole formation
por: Gupta, Akshari, et al.
Publicado: (2017)

Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine
por: Byrne, Matthew J., et al.
Publicado: (2020)

NEK1-Mediated Phosphorylation of YAP1 Is Key to Prostate Cancer Progression
por: Ghosh, Ishita, et al.
Publicado: (2023)

NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells
por: Pavan, Isadora Carolina Betim, et al.
Publicado: (2023)

Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization
por: Whelligan, Daniel K., et al.
Publicado: (2010)

The NIMA-family kinase, Nek1 affects the stability of centrosomes and ciliogenesis
por: White, Mark C, et al.
Publicado: (2008)

Role of NEK2A in Human Cancer and Its Therapeutic Potentials
por: Xia, Jiliang, et al.
Publicado: (2015)

An inhibitory role of NEK6 in TGFβ/Smad signaling pathway
por: Zuo, Jie, et al.
Publicado: (2015)

Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote metastasis
por: Das, T K, et al.
Publicado: (2013)

The Microtubule Regulator NEK7 Coordinates the Wiring of Cortical Parvalbumin Interneurons
por: Hinojosa, Antonio Jesús, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_tkivu05aqbeibvcdacc19gjup8