Cargando…

NBM-T-BBX-OS01, Semisynthesized from Osthole, Induced G1 Growth Arrest through HDAC6 Inhibition in Lung Cancer Cells

Disrupting lung tumor growth via histone deacetylases (HDACs) inhibition is a strategy for cancer therapy or prevention. Targeting HDAC6 may disturb the maturation of heat shock protein 90 (Hsp90) mediated cell cycle regulation. In this study, we demonstrated the effects of semisynthesized NBM-T-BBX...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pai, Jih-Tung, Hsu, Chia-Yun, Hua, Kuo-Tai, Yu, Sheng-Yung, Huang, Chung-Yang, Chen, Chia-Nan, Liao, Chiung-Ho, Weng, Meng-Shih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272357/ https://www.ncbi.nlm.nih.gov/pubmed/25946558 http://dx.doi.org/10.3390/molecules20058000

Ejemplares similares

NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats
por: Yang, Ying-Chen, et al.
Publicado: (2013)

Anti-Cancer Activity of an Osthole Derivative, NBM-T-BMX-OS01: Targeting Vascular Endothelial Growth Factor Receptor Signaling and Angiogenesis
por: Yang, Hung-Yu, et al.
Publicado: (2013)

NBM-HD-1: A Novel Histone Deacetylase Inhibitor with Anticancer Activity
por: Huang, Wei-Jan, et al.
Publicado: (2012)

Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6‐mediated matrix metalloproteinase 9
por: Pai, Jih‐Tung, et al.
Publicado: (2020)

NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the β-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhibition
por: Tsai, Cheng-Yu, et al.
Publicado: (2021)

BBX7 interacts with BBX8 to accelerate flowering in chrysanthemum
por: Zhai, Yiwen, et al.
Publicado: (2023)

The BBX gene CmBBX22 negatively regulates drought stress tolerance in chrysanthemum
por: Liu, Yanan, et al.
Publicado: (2022)

A Rice B-Box Protein, OsBBX14, Finely Regulates Anthocyanin Biosynthesis in Rice
por: Kim, Da-Hye, et al.
Publicado: (2018)

Propolin G-Suppressed Epithelial-to-Mesenchymal Transition in Triple-Negative Breast Cancer Cells via Glycogen Synthase Kinase 3β-Mediated Snail and HDAC6-Regulated Vimentin Degradation
por: Pai, Jih-Tung, et al.
Publicado: (2022)

A Positive Feedback Loop of BBX11–BBX21–HY5 Promotes Photomorphogenic Development in Arabidopsis
por: Zhao, Xianhai, et al.
Publicado: (2020)

OsBBX11 on qSTS4 links to salt tolerance at the seeding stage in Oryza sativa L. ssp. Japonica
por: Lei, Lei, et al.
Publicado: (2023)

Beyond Arabidopsis: BBX Regulators in Crop Plants
por: Talar, Urszula, et al.
Publicado: (2021)

Two B-Box Proteins, MaBBX20 and MaBBX51, Coordinate Light-Induced Anthocyanin Biosynthesis in Grape Hyacinth
por: Zhang, Han, et al.
Publicado: (2022)

Osthole inhibits proliferation of human breast cancer cells by inducing cell cycle arrest and apoptosis
por: Wang, Lintao, et al.
Publicado: (2015)

Anti-Leishmania Activity of Osthole
por: Kermani, Elaheh Kordzadeh, et al.
Publicado: (2016)

BBX24 Increases Saline and Osmotic Tolerance through ABA Signaling in Arabidopsis Seeds
por: Chiriotto, Tai S., et al.
Publicado: (2023)

Osthole extracted from a citrus fruit that affects apoptosis on A549 cell line by histone deacetylasese inhibition (HDACs)
por: Abosharaf, Hamed A., et al.
Publicado: (2020)

A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner
por: Zhang, Ge, et al.
Publicado: (2009)

Induction of G2/M Cell Cycle Arrest via p38/p21(Waf1/Cip1)-Dependent Signaling Pathway Activation by Bavachinin in Non-Small-Cell Lung Cancer Cells
por: Pai, Jih-Tung, et al.
Publicado: (2021)

Efficacy of Osthole in Management of Hypoperfused Retina
por: Du, Ran, et al.
Publicado: (2018)

AtBBX29 integrates photomorphogenesis and defense responses in Arabidopsis
por: Medina-Fraga, Ana L., et al.
Publicado: (2023)

Multi-layered roles of BBX proteins in plant growth and development
por: Cao, Jing, et al.
Publicado: (2023)

Mobile NBM - android medical mobile application designed to help in learning how to identify the different regions of interest in the brain’s white matter
por: Sánchez-Rola, Iskander, et al.
Publicado: (2014)

Pre-clinical 2D and 3D toxicity response to a panel of nanomaterials; comparative assessment of NBM-induced liver toxicity
por: Tutty, Melissa Anne, et al.
Publicado: (2022)

Osthole Attenuates Hepatic Injury in a Rodent Model of Trauma-Hemorrhage
por: Yu, Huang-Ping, et al.
Publicado: (2013)

Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation
por: Liu, Ya-Wei, et al.
Publicado: (2015)

Light and ripening-regulated BBX protein-encoding genes in Solanum lycopersicum
por: Lira, Bruno Silvestre, et al.
Publicado: (2020)

The Function of BBX Gene Family under Multiple Stresses in Nicotiana tabacum
por: Song, Kangkang, et al.
Publicado: (2022)

Genome-wide identification and expression pattern analysis of quinoa BBX family
por: Xuefen, Du, et al.
Publicado: (2022)

Osthole inhibits bone metastasis of breast cancer
por: Wu, Chunyu, et al.
Publicado: (2017)

The fluorescence of a mercury probe based on osthol
por: Luo, Guangyan, et al.
Publicado: (2021)

The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-Regulation
por: Chuang, Mei-Jen, et al.
Publicado: (2013)

Comparison of the Accuracy of Noninvasive Hemoglobin Sensor (NBM-200) and Portable Hemoglobinometer (HemoCue) with an Automated Hematology Analyzer (LH500) in Blood Donor Screening
por: Kim, Moon Jung, et al.
Publicado: (2013)

Expression of the Arabidopsis thaliana BBX32 Gene in Soybean Increases Grain Yield
por: Preuss, Sasha B., et al.
Publicado: (2012)

Genome-wide analysis of BBX gene family in Tartary buckwheat (Fagopyrum tataricum)
por: Zhao, Jiali, et al.
Publicado: (2021)

Identification of BBX gene family and its function in the regulation of microtuber formation in yam
por: Chang, Yingying, et al.
Publicado: (2023)

Genome-Wide Analysis of the BBX Genes in Platanus × acerifolia and Their Relationship with Flowering and/or Dormancy
por: Shi, Gehui, et al.
Publicado: (2023)

Fluorescence spectroscopy of osthole binding to human serum albumin
por: Yang, Guang-De, et al.
Publicado: (2013)

Review on the protective activity of osthole against the pathogenesis of osteoporosis
por: Chen, Jincai, et al.
Publicado: (2023)

Inhibitory Effects of Osthole on Human Breast Cancer Cell Progression via Induction of Cell Cycle Arrest, Mitochondrial Dysfunction, and ER Stress
por: Park, Wonhyoung, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ne04qhbvsd9vhu3dv9fu76gcb6