LC-ESI-MS/MS Analysis and Pharmacokinetics of GP205, an Innovative Potent Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease in Rats

A high-throughput, sensitive and specific LC-ESI-MS/MS method was established for the quantitative determination of GP205, a potent inhibitor of hepatitis C virus NS3/4A protease, in rat. The analyte was isolated from 25 μL plasma sample by 96-well LLE. Good linearity was achieved within the concent...

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Detalles Bibliográficos
Autores principales: Yang, Nan, Sun, Qiushi, Xu, Zihua, Wang, Xiuyun, Zhao, Xin, Cao, Yuqing, Chen, Li, Fan, Guorong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272426/
https://www.ncbi.nlm.nih.gov/pubmed/25756650
http://dx.doi.org/10.3390/molecules20034319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272426/
https://www.ncbi.nlm.nih.gov/pubmed/25756650
http://dx.doi.org/10.3390/molecules20034319

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