A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC(50) value of 1.57 µM against ac...

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Detalles Bibliográficos
Autores principales: Almansour, Abdulrahman I., Suresh Kumar, Raju, Arumugam, Natarajan, Basiri, Alireza, Kia, Yalda, Ali, Mohamed Ashraf, Farooq, Mehvish, Murugaiyah, Vikneswaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272427/
https://www.ncbi.nlm.nih.gov/pubmed/25642838
http://dx.doi.org/10.3390/molecules20022296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272427/
https://www.ncbi.nlm.nih.gov/pubmed/25642838
http://dx.doi.org/10.3390/molecules20022296

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