A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC(50) value of 1.57 µM against ac...

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Autores principales: Almansour, Abdulrahman I., Suresh Kumar, Raju, Arumugam, Natarajan, Basiri, Alireza, Kia, Yalda, Ali, Mohamed Ashraf, Farooq, Mehvish, Murugaiyah, Vikneswaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272427/
https://www.ncbi.nlm.nih.gov/pubmed/25642838
http://dx.doi.org/10.3390/molecules20022296
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author Almansour, Abdulrahman I.
Suresh Kumar, Raju
Arumugam, Natarajan
Basiri, Alireza
Kia, Yalda
Ali, Mohamed Ashraf
Farooq, Mehvish
Murugaiyah, Vikneswaran
author_facet Almansour, Abdulrahman I.
Suresh Kumar, Raju
Arumugam, Natarajan
Basiri, Alireza
Kia, Yalda
Ali, Mohamed Ashraf
Farooq, Mehvish
Murugaiyah, Vikneswaran
author_sort Almansour, Abdulrahman I.
collection PubMed
description A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC(50) value of 1.57 µM against acethylcholinesterase (AChE). Molecular docking simulation for the most active compound was employed with the aim of disclosing its binding mechanism to the active site of AChE receptor.
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spelling pubmed-62724272018-12-13 A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines Almansour, Abdulrahman I. Suresh Kumar, Raju Arumugam, Natarajan Basiri, Alireza Kia, Yalda Ali, Mohamed Ashraf Farooq, Mehvish Murugaiyah, Vikneswaran Molecules Article A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC(50) value of 1.57 µM against acethylcholinesterase (AChE). Molecular docking simulation for the most active compound was employed with the aim of disclosing its binding mechanism to the active site of AChE receptor. MDPI 2015-01-29 /pmc/articles/PMC6272427/ /pubmed/25642838 http://dx.doi.org/10.3390/molecules20022296 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Almansour, Abdulrahman I.
Suresh Kumar, Raju
Arumugam, Natarajan
Basiri, Alireza
Kia, Yalda
Ali, Mohamed Ashraf
Farooq, Mehvish
Murugaiyah, Vikneswaran
A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
title A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
title_full A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
title_fullStr A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
title_full_unstemmed A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
title_short A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
title_sort facile ionic liquid promoted synthesis, cholinesterase inhibitory activity and molecular modeling study of novel highly functionalized spiropyrrolidines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272427/
https://www.ncbi.nlm.nih.gov/pubmed/25642838
http://dx.doi.org/10.3390/molecules20022296
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