Synthesis and Biological Evaluation of Novel Water-Soluble Poly-(ethylene glycol)-10-hydroxycamptothecin Conjugates

In order to improve the antitumor activity and water solubility of 10-hydroxycamptothecin (HCPT), a series of novel HCPT conjugates were designed and synthesized by conjugating polyethylene glycol (PEG) to the 10-hydroxyl group of HCPT via a valine spacer. The in vitro stability of these synthesized...

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Detalles Bibliográficos
Autores principales: Guo, Na, Jiang, Du, Wang, Luyao, You, Xing, Teng, Yu-Ou, Yu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272474/
https://www.ncbi.nlm.nih.gov/pubmed/26007190
http://dx.doi.org/10.3390/molecules20059393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272474/
https://www.ncbi.nlm.nih.gov/pubmed/26007190
http://dx.doi.org/10.3390/molecules20059393

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