Enhanced Supersaturation and Oral Absorption of Sirolimus Using an Amorphous Solid Dispersion Based on Eudragit(®) E

The present study aimed to investigate the effect of Eudragit(®) E/HCl (E-SD) on the degradation of sirolimus in simulated gastric fluid (pH 1.2) and to develop a new oral formulation of sirolimus using E-SD solid dispersions to enhance oral bioavailability. Sirolimus-loaded solid dispersions were f...

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Detalles Bibliográficos
Autores principales: Cho, Youngseok, Ha, Eun-Sol, Baek, In-Hwan, Kim, Min-Soo, Cho, Cheong-Weon, Hwang, Sung-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272523/
https://www.ncbi.nlm.nih.gov/pubmed/26020699
http://dx.doi.org/10.3390/molecules20069496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272523/
https://www.ncbi.nlm.nih.gov/pubmed/26020699
http://dx.doi.org/10.3390/molecules20069496

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