Pi-pi Stacking Mediated Cooperative Mechanism for Human Cytochrome P450 3A4

Human Cytochrome P450 3A4 (CYP3A4) is an important member of the cytochrome P450 superfamily with responsibility for metabolizing ~50% of clinical drugs. Experimental evidence showed that CYP3A4 can adopt multiple substrates in its active site to form a cooperative binding model, accelerating substr...

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Detalles Bibliográficos
Autores principales: Fa, Botao, Cong, Shan, Wang, Jingfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272561/
https://www.ncbi.nlm.nih.gov/pubmed/25919277
http://dx.doi.org/10.3390/molecules20057558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272561/
https://www.ncbi.nlm.nih.gov/pubmed/25919277
http://dx.doi.org/10.3390/molecules20057558

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