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Pi-pi Stacking Mediated Cooperative Mechanism for Human Cytochrome P450 3A4

Human Cytochrome P450 3A4 (CYP3A4) is an important member of the cytochrome P450 superfamily with responsibility for metabolizing ~50% of clinical drugs. Experimental evidence showed that CYP3A4 can adopt multiple substrates in its active site to form a cooperative binding model, accelerating substr...

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Detalles Bibliográficos
Autores principales:	Fa, Botao, Cong, Shan, Wang, Jingfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272561/ https://www.ncbi.nlm.nih.gov/pubmed/25919277 http://dx.doi.org/10.3390/molecules20057558

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