Development and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors

The human muscle isoform of lactate dehydrogenase (hLDH5) is one of the key enzymes of the glycolytic process. It is overexpressed in metastatic cancer cells and is linked to the vitality of tumors in hypoxic conditions. With the aim of identifying new hLDH5 inhibitors, a fully automated docking-bas...

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Detalles Bibliográficos
Autores principales: Granchi, Carlotta, Capecchi, Alice, Del Frate, Gianluca, Martinelli, Adriano, Macchia, Marco, Minutolo, Filippo, Tuccinardi, Tiziano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272605/
https://www.ncbi.nlm.nih.gov/pubmed/25988609
http://dx.doi.org/10.3390/molecules20058772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272605/
https://www.ncbi.nlm.nih.gov/pubmed/25988609
http://dx.doi.org/10.3390/molecules20058772

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