Structure-Based Virtual Screening of Novel Natural Alkaloid Derivatives as Potential Binders of h-telo and c-myc DNA G-Quadruplex Conformations

Several ligands can bind to the non-canonical G-quadruplex DNA structures thereby stabilizing them. These molecules can act as effective anticancer agents by stabilizing the telomeric regions of DNA or by regulating oncogene expression. In order to better interact with the quartets of G-quadruplex s...

Descripción completa

Detalles Bibliográficos
Autores principales: Rocca, Roberta, Moraca, Federica, Costa, Giosuè, Alcaro, Stefano, Distinto, Simona, Maccioni, Elias, Ortuso, Francesco, Artese, Anna, Parrotta, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272608/
https://www.ncbi.nlm.nih.gov/pubmed/25547724
http://dx.doi.org/10.3390/molecules20010206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272608/
https://www.ncbi.nlm.nih.gov/pubmed/25547724
http://dx.doi.org/10.3390/molecules20010206

Ejemplares similares