An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions

We report here an efficient and green method for Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea catalyzed by Brønsted acidic ionic liquid [Btto][p-TSA] under solvent-free conditions. Compared to the classical Biginelli reaction conditions, the present method has the...

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Detalles Bibliográficos
Autores principales: Zhang, Yonghong, Wang, Bin, Zhang, Xiaomei, Huang, Jianbin, Liu, Chenjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272654/
https://www.ncbi.nlm.nih.gov/pubmed/25730389
http://dx.doi.org/10.3390/molecules20033811
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author Zhang, Yonghong
Wang, Bin
Zhang, Xiaomei
Huang, Jianbin
Liu, Chenjiang
author_facet Zhang, Yonghong
Wang, Bin
Zhang, Xiaomei
Huang, Jianbin
Liu, Chenjiang
author_sort Zhang, Yonghong
collection PubMed
description We report here an efficient and green method for Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea catalyzed by Brønsted acidic ionic liquid [Btto][p-TSA] under solvent-free conditions. Compared to the classical Biginelli reaction conditions, the present method has the advantages of giving good yields, short reaction times, near room temperature conditions and the avoidance of the use of organic solvents and metal catalyst.
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spelling pubmed-62726542018-12-31 An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions Zhang, Yonghong Wang, Bin Zhang, Xiaomei Huang, Jianbin Liu, Chenjiang Molecules Article We report here an efficient and green method for Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea catalyzed by Brønsted acidic ionic liquid [Btto][p-TSA] under solvent-free conditions. Compared to the classical Biginelli reaction conditions, the present method has the advantages of giving good yields, short reaction times, near room temperature conditions and the avoidance of the use of organic solvents and metal catalyst. MDPI 2015-02-26 /pmc/articles/PMC6272654/ /pubmed/25730389 http://dx.doi.org/10.3390/molecules20033811 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Yonghong
Wang, Bin
Zhang, Xiaomei
Huang, Jianbin
Liu, Chenjiang
An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions
title An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions
title_full An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions
title_fullStr An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions
title_full_unstemmed An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions
title_short An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions
title_sort efficient synthesis of 3,4-dihydropyrimidin-2(1h)-ones and thiones catalyzed by a novel brønsted acidic ionic liquid under solvent-free conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272654/
https://www.ncbi.nlm.nih.gov/pubmed/25730389
http://dx.doi.org/10.3390/molecules20033811
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