5-Methoxyquinoline Derivatives as a New Class of EZH2 Inhibitors

A series of quinoline derivatives was synthesized and biologically evaluated as Enhancer of Zeste Homologue 2 (EZH2) inhibitors. Structure-activity relationship (SAR) studies led to the discovery of 5-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinolin-4-amine (5k), which displ...

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Detalles Bibliográficos
Autores principales: Xiang, Pu, Jie, Hui, Zhou, Yang, Yang, Bo, Wang, Hui-Juan, Hu, Jing, Hu, Jian, Yang, Sheng-Yong, Zhao, Ying-Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272711/
https://www.ncbi.nlm.nih.gov/pubmed/25923513
http://dx.doi.org/10.3390/molecules20057620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272711/
https://www.ncbi.nlm.nih.gov/pubmed/25923513
http://dx.doi.org/10.3390/molecules20057620

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