Discovery of Novel Small Molecule Anti-HCV Agents via the CypA Inhibitory Mechanism Using O-Acylation-Directed Lead Optimization

In this work, the relationship between cyclophilin A (CypA) and HCV prompted us to screen a series of small molecule CypA inhibitors which were previously reported by our group. Among them, compound 1, discovered as a non-immunosuppressive anti-HCV agent with an EC(50) value of 0.67 μM in a virus as...

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Detalles Bibliográficos
Autores principales: Yan, Wenzhong, Qing, Jie, Mei, Hanbing, Mao, Fei, Huang, Jin, Zhu, Jin, Jiang, Hualiang, Liu, Lei, Zhang, Linqi, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272715/
https://www.ncbi.nlm.nih.gov/pubmed/26053489
http://dx.doi.org/10.3390/molecules200610342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272715/
https://www.ncbi.nlm.nih.gov/pubmed/26053489
http://dx.doi.org/10.3390/molecules200610342

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