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4-[(18)F]Fluorophenylpiperazines by Improved Hartwig-Buchwald N-Arylation of 4-[(18)F]fluoroiodobenzene, Formed via Hypervalent λ(3)-Iodane Precursors: Application to Build-Up of the Dopamine D(4) Ligand [(18)F]FAUC 316

Substituted phenylpiperazines are often neuropharmacologically active compounds and in many cases are essential pharmacophores of neuroligands for different receptors such as D(2)-like dopaminergic, serotoninergic and other receptors. Nucleophilic, no-carrier-added (n.c.a.) (18)F-labelling of these...

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Detalles Bibliográficos
Autores principales:	Kügler, Fabian, Ermert, Johannes, Kaufholz, Peter, Coenen, Heinz H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272738/ https://www.ncbi.nlm.nih.gov/pubmed/25558857 http://dx.doi.org/10.3390/molecules20010470

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