Synthesis, In-Vitro Antibacterial, Antifungal, and Molecular Modeling of Potent Anti-Microbial Agents with a Combined Pyrazole and Thiophene Pharmacophore

Ethyl 5-acetyl-4-methyl-2-(phenylamino)thiophene-3-carboxylate (2) and there derivatives 3a–c, 4, 6a–c and 9a–f were synthesized. The structure of compound 2 was deduced by (1)H-NMR, (13)C-NMR, FT-IR, MS, microanalysis, and single-crystal X-ray crystallography. The compound crystallized in the monoc...

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Detalles Bibliográficos
Autores principales: Mabkhot, Yahia Nasser, Ahmed Kaal, Nahed, Alterary, Seham, Al-Showiman, Salim S., Barakat, Assem, Ghabbour, Hazem A., Frey, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272790/
https://www.ncbi.nlm.nih.gov/pubmed/26007175
http://dx.doi.org/10.3390/molecules20058712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272790/
https://www.ncbi.nlm.nih.gov/pubmed/26007175
http://dx.doi.org/10.3390/molecules20058712

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