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The C-Terminal O-S Acyl Shift Pathway under Acidic Condition to Propose Peptide-Thioesters
Peptide-thioester is a pivotal intermediate for peptide ligation and N-, C-terminal cyclization. In this study, desired pathway and the side products of two C-terminal handles, hydroxyethylthiol (HET) and hydroxypropylthiol (HPT) are described in different conditions as well as kinetic studies. In a...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272864/ https://www.ncbi.nlm.nih.gov/pubmed/27869694 http://dx.doi.org/10.3390/molecules21111559 |