Cargando…

Synthesis and Evaluation of Bicyclo[3.1.0]hexane-Based UDP-Galf Analogues as Inhibitors of the Mycobacterial Galactofuranosyltransferase GlfT2

UDP-galactofuranose (UDP-Galf) is the donor substrate for both bifunctional galactofuranosyltransferases, GlfT1 and GlfT2, which are involved in the biosynthesis of mycobacterial galactan. In this paper, a group of UDP-Galf mimics were synthesized via reductive amination of a bicyclo[3.1.0]hexane-ba...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lowary, Todd L., Li, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272867/ https://www.ncbi.nlm.nih.gov/pubmed/27529206 http://dx.doi.org/10.3390/molecules21081053

Ejemplares similares

Potential Inhibitors of Galactofuranosyltransferase 2 (GlfT2): Molecular Docking, 3D-QSAR, and In Silico ADMETox Studies
por: Ortiz, Christopher Llynard D., et al.
Publicado: (2019)

Synthesis, docking study and biological evaluation of ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones as potential inhibitors of the mycobacterial galactan synthesis targeting the galactofuranosyltransferase GlfT2
por: Baráth, Marek, et al.
Publicado: (2020)

Catalytic Mechanism of Processive GlfT2: Transition Path Sampling Investigation of Substrate Translocation
por: Janoš, Pavel, et al.
Publicado: (2020)

Synthesis of bicyclo[3.1.0]hexanes by (3 + 2) annulation of cyclopropenes with aminocyclopropanes
por: Muriel, Bastian, et al.
Publicado: (2019)

On the Ancestral UDP-Glucose Pyrophosphorylase Activity of GalF from Escherichia coli
por: Ebrecht, Ana C., et al.
Publicado: (2015)

Biological Evaluation of 3-Azaspiro[Bicyclo[3.1.0]Hexane-2,5′-Pyrimidines] as Potential Antitumor Agents
por: Shmakov, Stanislav V., et al.
Publicado: (2022)

2-(Methoxymethoxy)-1-(4-oxobicyclo[3.1.0]hexan-1-yl)ethyl 4-nitrobenzoate
por: Li, Jing, et al.
Publicado: (2007)

(1S,5R)-1-(4-Fluorophenyl)-3-azoniabicyclo[3.1.0]hexane chloride
por: Görbitz, Carl Henrik, et al.
Publicado: (2009)

Development of Bicyclo[3.1.0]hexane-Based A(3) Receptor Ligands: Closing the Gaps in the Structure–Affinity Relationships
por: Lemmerhirt, Jan Phillip, et al.
Publicado: (2022)

Conformational Restriction of Histamine with a Rigid Bicyclo[3.1.0]hexane Scaffold Provided Selective H(3) Receptor Ligands
por: Watanabe, Mizuki, et al.
Publicado: (2020)

(1R,2R,3R,4R,5S)-2,3-Bis[(2S′)-2-acetoxy-2-phenylacetoxy]-4-azido-1-[(2,4-dinitrophenyl)hydrazonomethyl]bicyclo[3.1.0]hexane
por: Li, Jing, et al.
Publicado: (2008)

(1S,5R)-1-(3,4-Dichlorophenyl)-3-oxabicyclo[3.1.0]hexan-2-one
por: Görbitz, Carl Henrik, et al.
Publicado: (2009)

Radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters
por: Ye, Liu, et al.
Publicado: (2018)

The LPG1x family from Leishmania major is constituted of rare eukaryotic galactofuranosyltransferases with unprecedented catalytic properties
por: Ati, Jihen, et al.
Publicado: (2018)

Synthesis of enantiomerically pure d- and l-bicyclo[3.1.0]hexenyl carbanucleosides and their antiviral evaluation
por: Park, Ah-Young, et al.
Publicado: (2011)

Ethyl 2-(4-methoxyphenyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate: crystal structure and Hirshfeld analysis
por: Zukerman-Schpector, Julio, et al.
Publicado: (2017)

Synthesis of CHF(2)-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF(2)-pyrazolines
por: Zheng, Yang, et al.
Publicado: (2018)

endo-3,3-Dimethyl-4-oxobicyclo[3.1.0]hexan-2-yl methanesulfonate
por: Kremer, Adrian, et al.
Publicado: (2010)

Impact of Excited-State Antiaromaticity Relief in a Fundamental Benzene Photoreaction Leading to Substituted Bicyclo[3.1.0]hexenes
por: Slanina, Tomáš, et al.
Publicado: (2020)

(1′S,4′S)-5-(2,5-Dimethylphenyl)-4′-methoxy-6-oxa-3-azaspiro[bicyclo[3.1.0]hexane-2,1′-cyclohexan]-4-one
por: He, Xing-Rui, et al.
Publicado: (2013)

Synthesis of polysubstituted bicyclo[2.1.1]hexanes enabling access to new chemical space
por: Reinhold, Marius, et al.
Publicado: (2023)

Twenty Years of Mycobacterial Glycans: Furanosides and Beyond
por: Lowary, Todd L.
Publicado: (2016)

Functional analysis of three putative galactofuranosyltransferases with redundant functions in galactofuranosylation in Aspergillus niger
por: Arentshorst, Mark, et al.
Publicado: (2019)

2,5-disubstituted bicyclo[2.1.1]hexanes as rigidified cyclopentane variants
por: Paul, Shashwati, et al.
Publicado: (2023)

(1R,3R,4R,6S)-4-(7-Methoxy-2-oxo-2H-chromen-6-yl)-1-methyl-3,6-dioxabicyclo[3.1.0]hexan-2-yl acetate
por: Phakhodee, Wong, et al.
Publicado: (2012)

Chemistry of polyhalogenated nitrobutadienes, 10: Synthesis of highly functionalized heterocycles with a rigid 6-amino-3-azabicyclo[3.1.0]hexane moiety
por: Zapol’skii, Viktor A, et al.
Publicado: (2012)

Directed evolution of Zymomonas mobilis sugar facilitator Glf to overcome glucose inhibition
por: Kurgan, Gavin, et al.
Publicado: (2021)

(1SR,2RS,3SR,5SR,6RS)-6-[(Z)-1-Acetoxy-2-phenylethenyl]-3-ethoxy-2-phenylbicyclo[3.1.0]hexan-1-yl acetate
por: Hu, Wen-Xiang, et al.
Publicado: (2011)

Lewis acid catalyzed heavy atom tunneling – the case of 1H-bicyclo[3.1.0]-hexa-3,5-dien-2-one
por: Henkel, Stefan, et al.
Publicado: (2021)

Synthesis of bis-spirocyclic derivatives of 3-azabicyclo[3.1.0]hexane via cyclopropene cycloadditions to the stable azomethine ylide derived from Ruhemann's purple
por: Filatov, Alexander S, et al.
Publicado: (2022)

Galactofuranose (Galf)-containing sugar chain contributes to the hyphal growth, conidiation and virulence of F. oxysporum f.sp. cucumerinum
por: Zhou, Hui, et al.
Publicado: (2021)

UDP-xylose and UDP-galactose synthesis in Trichomonas vaginalis
por: Rosenberger, Andrea F.N., et al.
Publicado: (2012)

Methodology for the Construction of the Bicyclo[4.3.0]nonane Core
por: Eddy, Nicholas A., et al.
Publicado: (2016)

Synthesis and Biological Evaluation of Bicyclo[1.1.1]pentane-Containing Aromatic Lipoxin A(4) Analogues
por: Owen, Benjamin, et al.
Publicado: (2022)

Selective and reversible 1,3-dipolar cycloaddition of 6-aryl-1,5-diazabicyclo[3.1.0]hexanes with 1,3-diphenylprop-2-en-1-ones under microwave irradiation
por: Molchanov, Alexander P, et al.
Publicado: (2020)

Synthetic biology open language (SBOL) version 3.1.0
por: Buecherl, Lukas, et al.
Publicado: (2023)

Strain-promoted sydnone bicyclo-[6.1.0]-nonyne cycloaddition
por: Wallace, Stephen, et al.
Publicado: (2014)

Draft Genome Sequences of Aggregatibacter actinomycetemcomitans Strains 310a and 310b
por: May, Anthony C., et al.
Publicado: (2017)

Crystal structures of two bicyclo[5.1.0]octanes: potassium trans-bicyclo[5.1.0]octane-4-carboxylate monohydrate and cis-bicyclo[5.1.0]octan-4-yl 4-bromobenzenesulfonate
por: Corfield, Peter W. R., et al.
Publicado: (2017)

Trypanosoma brucei UDP-galactose-4′-epimerase in ternary complex with NAD(+) and the substrate analogue UDP-4-deoxy-4-fluoro-α-d-galactose
por: Alphey, Magnus S., et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_4n2vn3nlmfvotcctockooimp6p