Synthesis and Structure-Activity Relationship Analysis of 5-HT(7) Receptor Antagonists: Piperazin-1-yl Substituted Unfused Heterobiaryls

A series of piperazin-1-yl substituted unfused heterobiaryls was synthesized as ligands of the 5-HT(7) receptors. The goal of this project was to elucidate the structural features that affect the 5-HT(7) binding affinity of this class of compounds represented by the model ligand 4-(3-furyl)-2-(4-met...

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Detalles Bibliográficos
Autores principales: Strekowski, Lucjan, Sączewski, Jarosław, Raux, Elizabeth A., Fernando, Nilmi T., Klenc, Jeff, Paranjpe, Shirish, Raszkiewicz, Aldona, Blake, Ava L., Ehalt, Adam J., Barnes, Samuel, Baranowski, Timothy C., Sullivan, Shannon M., Satała, Grzegorz, Bojarski, Andrzej J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272903/
https://www.ncbi.nlm.nih.gov/pubmed/27043518
http://dx.doi.org/10.3390/molecules21040433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272903/
https://www.ncbi.nlm.nih.gov/pubmed/27043518
http://dx.doi.org/10.3390/molecules21040433

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