Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3′-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease

Nucleoside/nucleotide analogs that lack the 3′-hydroxy group are widely utilized for HIV therapy. These chain-terminating nucleoside analogs (CTNAs) block DNA synthesis after their incorporation into growing DNA, leading to the antiviral effects. However, they are also considered to be DNA damaging...

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Detalles Bibliográficos
Autores principales: Yamamoto, Junpei, Takahata, Chiaki, Kuraoka, Isao, Hirota, Kouji, Iwai, Shigenori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273010/
https://www.ncbi.nlm.nih.gov/pubmed/27294910
http://dx.doi.org/10.3390/molecules21060766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273010/
https://www.ncbi.nlm.nih.gov/pubmed/27294910
http://dx.doi.org/10.3390/molecules21060766

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