The Complexity of Targeting PI3K-Akt-mTOR Signalling in Human Acute Myeloid Leukaemia: The Importance of Leukemic Cell Heterogeneity, Neighbouring Mesenchymal Stem Cells and Immunocompetent Cells

Therapeutic targeting of PI3K-Akt-mTOR is considered a possible strategy in human acute myeloid leukaemia (AML); the most important rationale being the proapoptotic and antiproliferative effects of direct PI3K/mTOR inhibition observed in experimental studies of human AML cells. However, AML is a het...

Descripción completa

Detalles Bibliográficos
Autores principales: Brenner, Annette K., Andersson Tvedt, Tor Henrik, Bruserud, Øystein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273124/
https://www.ncbi.nlm.nih.gov/pubmed/27845732
http://dx.doi.org/10.3390/molecules21111512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273124/
https://www.ncbi.nlm.nih.gov/pubmed/27845732
http://dx.doi.org/10.3390/molecules21111512

Ejemplares similares