Ultrasound Mediated One-Pot, Three Component Synthesis, Docking and ADME Prediction of Novel 5-Amino-2-(4-chlorophenyl)-7-Substituted Phenyl-8,8a-dihydro-7H-(1,3,4)thiadiazolo(3,2-α)pyrimidine-6-carbonitrile Derivatives as Anticancer Agents

Herein, we report an environmentally friendly, rapid, and convenient one-pot ultrasound-promoted synthesis of 5-amino-2-(4-chlorophenyl)-7-substituted phenyl-8,8a-dihydro-7H-(1,3,4)thiadiazolo(3,2-α)pyrimidine-6-carbonitrile derivatives. The in-vitro anticancer activities of these compounds were eva...

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Detalles Bibliográficos
Autores principales: Tiwari, Shailee V., Seijas, Julio A., Vazquez-Tato, M. Pilar, Sarkate, Aniket P., Lokwani, Deepak K., Nikalje, Anna Pratima G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273159/
https://www.ncbi.nlm.nih.gov/pubmed/27483213
http://dx.doi.org/10.3390/molecules21080894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273159/
https://www.ncbi.nlm.nih.gov/pubmed/27483213
http://dx.doi.org/10.3390/molecules21080894

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