Cargando…

Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L.

Methanolic extracts from the aerial parts and roots of two Scutellaria species, S. alpina and S. altissima, and five polyphenols from these plants demonstrated a significant ability to inhibit the formation of advanced glycation end-products (AGE) in vitro. S. alpina, which is richer in polyphenolic...

Descripción completa

Detalles Bibliográficos
Autores principales: Grzegorczyk-Karolak, Izabela, Gołąb, Krzysztof, Gburek, Jakub, Wysokińska, Halina, Matkowski, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273165/
https://www.ncbi.nlm.nih.gov/pubmed/27314314
http://dx.doi.org/10.3390/molecules21060739
_version_ 1783377321557753856
author Grzegorczyk-Karolak, Izabela
Gołąb, Krzysztof
Gburek, Jakub
Wysokińska, Halina
Matkowski, Adam
author_facet Grzegorczyk-Karolak, Izabela
Gołąb, Krzysztof
Gburek, Jakub
Wysokińska, Halina
Matkowski, Adam
author_sort Grzegorczyk-Karolak, Izabela
collection PubMed
description Methanolic extracts from the aerial parts and roots of two Scutellaria species, S. alpina and S. altissima, and five polyphenols from these plants demonstrated a significant ability to inhibit the formation of advanced glycation end-products (AGE) in vitro. S. alpina, which is richer in polyphenolic compounds, had strong antiglycation properties. These extracts demonstrated also high activity in the FRAP (ferric-reducing antioxidant power), antiradical (DPPH) and lipid peroxidation inhibition assays. Among the pure compounds, baicalin was the strongest glycation inhibitor (90.4% inhibition at 100 μg/mL), followed by luteolin (85.4%). Two other flavone glycosides had about half of this activity. Verbascoside was similar to the reference drug aminoguanidine (71.2% and 75.9%, respectively). The strong correlation observed between AGE inhibition and total flavonoid content indicated that flavonoids contribute significantly to antiglycation properties. A positive correlation was also observed between antiglycative and antioxidant activities. The studied skullcap species can be considered as a potential source of therapeutic agents for hyperglycemia-related disorders.
format Online
Article
Text
id pubmed-6273165
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62731652018-12-28 Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L. Grzegorczyk-Karolak, Izabela Gołąb, Krzysztof Gburek, Jakub Wysokińska, Halina Matkowski, Adam Molecules Article Methanolic extracts from the aerial parts and roots of two Scutellaria species, S. alpina and S. altissima, and five polyphenols from these plants demonstrated a significant ability to inhibit the formation of advanced glycation end-products (AGE) in vitro. S. alpina, which is richer in polyphenolic compounds, had strong antiglycation properties. These extracts demonstrated also high activity in the FRAP (ferric-reducing antioxidant power), antiradical (DPPH) and lipid peroxidation inhibition assays. Among the pure compounds, baicalin was the strongest glycation inhibitor (90.4% inhibition at 100 μg/mL), followed by luteolin (85.4%). Two other flavone glycosides had about half of this activity. Verbascoside was similar to the reference drug aminoguanidine (71.2% and 75.9%, respectively). The strong correlation observed between AGE inhibition and total flavonoid content indicated that flavonoids contribute significantly to antiglycation properties. A positive correlation was also observed between antiglycative and antioxidant activities. The studied skullcap species can be considered as a potential source of therapeutic agents for hyperglycemia-related disorders. MDPI 2016-06-14 /pmc/articles/PMC6273165/ /pubmed/27314314 http://dx.doi.org/10.3390/molecules21060739 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grzegorczyk-Karolak, Izabela
Gołąb, Krzysztof
Gburek, Jakub
Wysokińska, Halina
Matkowski, Adam
Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L.
title Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L.
title_full Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L.
title_fullStr Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L.
title_full_unstemmed Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L.
title_short Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L.
title_sort inhibition of advanced glycation end-product formation and antioxidant activity by extracts and polyphenols from scutellaria alpina l. and s. altissima l.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273165/
https://www.ncbi.nlm.nih.gov/pubmed/27314314
http://dx.doi.org/10.3390/molecules21060739
work_keys_str_mv AT grzegorczykkarolakizabela inhibitionofadvancedglycationendproductformationandantioxidantactivitybyextractsandpolyphenolsfromscutellariaalpinalandsaltissimal
AT gołabkrzysztof inhibitionofadvancedglycationendproductformationandantioxidantactivitybyextractsandpolyphenolsfromscutellariaalpinalandsaltissimal
AT gburekjakub inhibitionofadvancedglycationendproductformationandantioxidantactivitybyextractsandpolyphenolsfromscutellariaalpinalandsaltissimal
AT wysokinskahalina inhibitionofadvancedglycationendproductformationandantioxidantactivitybyextractsandpolyphenolsfromscutellariaalpinalandsaltissimal
AT matkowskiadam inhibitionofadvancedglycationendproductformationandantioxidantactivitybyextractsandpolyphenolsfromscutellariaalpinalandsaltissimal