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Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development

Dimethylarginine dimethylaminohydrolase (DDAH) is a highly conserved hydrolytic enzyme found in numerous species, including bacteria, rodents, and humans. In humans, the DDAH-1 isoform is known to metabolize endogenous asymmetric dimethylarginine (ADMA) and monomethyl arginine (l-NMMA), with ADMA pr...

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Detalles Bibliográficos
Autores principales:	Murphy, Rhys B., Tommasi, Sara, Lewis, Benjamin C., Mangoni, Arduino A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273216/ https://www.ncbi.nlm.nih.gov/pubmed/27187323 http://dx.doi.org/10.3390/molecules21050615

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