Cellular Uptake and Photo-Cytotoxicity of a Gadolinium(III)-DOTA-Naphthalimide Complex “Clicked” to a Lipidated Tat Peptide

A new bifunctional macrocyclic chelator featuring a conjugatable alkynyl-naphthalimide fluorophore pendant group has been prepared and its Gd(III) complex coupled to a cell-penetrating lipidated azido-Tat peptide derivative using Cu(I)-catalysed “click” chemistry. The resulting fluorescent conjugate...

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Detalles Bibliográficos
Autores principales: O’Malley, William I., Rubbiani, Riccardo, Aulsebrook, Margaret L., Grace, Michael R., Spiccia, Leone, Tuck, Kellie L., Gasser, Gilles, Graham, Bim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273236/
https://www.ncbi.nlm.nih.gov/pubmed/26861271
http://dx.doi.org/10.3390/molecules21020194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273236/
https://www.ncbi.nlm.nih.gov/pubmed/26861271
http://dx.doi.org/10.3390/molecules21020194

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