Discovery of a New Class of Sortase A Transpeptidase Inhibitors to Tackle Gram-Positive Pathogens: 2-(2-Phenylhydrazinylidene)alkanoic Acids and Related Derivatives

A FRET-based random screening assay was used to generate hit compounds as sortase A inhibitors that allowed us to identify ethyl 3-oxo-2-(2-phenylhydrazinylidene)butanoate as an example of a new class of sortase A inhibitors. Other analogues were generated by changing the ethoxycarbonyl function for...

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Detalles Bibliográficos
Autores principales: Maggio, Benedetta, Raffa, Demetrio, Raimondi, Maria Valeria, Cascioferro, Stella, Plescia, Fabiana, Schillaci, Domenico, Cusimano, Maria Grazia, Leonchiks, Ainars, Zhulenkovs, Dmitrijs, Basile, Livia, Daidone, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273394/
https://www.ncbi.nlm.nih.gov/pubmed/26907235
http://dx.doi.org/10.3390/molecules21020241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273394/
https://www.ncbi.nlm.nih.gov/pubmed/26907235
http://dx.doi.org/10.3390/molecules21020241

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