LC-MS Supported Studies on the in Vitro Metabolism of both Enantiomers of Flubatine and the in Vivo Metabolism of (+)-[(18)F]Flubatine—A Positron Emission Tomography Radioligand for Imaging α4β2 Nicotinic Acetylcholine Receptors

Both enantiomers of [(18)F]flubatine are promising radioligands for neuroimaging of α4β2 nicotinic acetylcholine receptors (nAChRs) by positron emission tomography (PET). To support clinical studies in patients with early Alzheimer’s disease, a detailed examination of the metabolism in vitro and in...

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Detalles Bibliográficos
Autores principales: Ludwig, Friedrich-Alexander, Smits, René, Fischer, Steffen, Donat, Cornelius K., Hoepping, Alexander, Brust, Peter, Steinbach, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273452/
https://www.ncbi.nlm.nih.gov/pubmed/27617996
http://dx.doi.org/10.3390/molecules21091200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273452/
https://www.ncbi.nlm.nih.gov/pubmed/27617996
http://dx.doi.org/10.3390/molecules21091200

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