The Prodrug Approach: A Successful Tool for Improving Drug Solubility

Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug developme...

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Detalles Bibliográficos
Autores principales: Jornada, Daniela Hartmann, dos Santos Fernandes, Guilherme Felipe, Chiba, Diego Eidy, de Melo, Thais Regina Ferreira, dos Santos, Jean Leandro, Chung, Man Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273601/
https://www.ncbi.nlm.nih.gov/pubmed/26729077
http://dx.doi.org/10.3390/molecules21010042
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author Jornada, Daniela Hartmann
dos Santos Fernandes, Guilherme Felipe
Chiba, Diego Eidy
de Melo, Thais Regina Ferreira
dos Santos, Jean Leandro
Chung, Man Chin
author_facet Jornada, Daniela Hartmann
dos Santos Fernandes, Guilherme Felipe
Chiba, Diego Eidy
de Melo, Thais Regina Ferreira
dos Santos, Jean Leandro
Chung, Man Chin
author_sort Jornada, Daniela Hartmann
collection PubMed
description Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years.
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spelling pubmed-62736012018-12-28 The Prodrug Approach: A Successful Tool for Improving Drug Solubility Jornada, Daniela Hartmann dos Santos Fernandes, Guilherme Felipe Chiba, Diego Eidy de Melo, Thais Regina Ferreira dos Santos, Jean Leandro Chung, Man Chin Molecules Review Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years. MDPI 2015-12-29 /pmc/articles/PMC6273601/ /pubmed/26729077 http://dx.doi.org/10.3390/molecules21010042 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jornada, Daniela Hartmann
dos Santos Fernandes, Guilherme Felipe
Chiba, Diego Eidy
de Melo, Thais Regina Ferreira
dos Santos, Jean Leandro
Chung, Man Chin
The Prodrug Approach: A Successful Tool for Improving Drug Solubility
title The Prodrug Approach: A Successful Tool for Improving Drug Solubility
title_full The Prodrug Approach: A Successful Tool for Improving Drug Solubility
title_fullStr The Prodrug Approach: A Successful Tool for Improving Drug Solubility
title_full_unstemmed The Prodrug Approach: A Successful Tool for Improving Drug Solubility
title_short The Prodrug Approach: A Successful Tool for Improving Drug Solubility
title_sort prodrug approach: a successful tool for improving drug solubility
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273601/
https://www.ncbi.nlm.nih.gov/pubmed/26729077
http://dx.doi.org/10.3390/molecules21010042
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