Extended N-Arylsulfonylindoles as 5-HT(6) Receptor Antagonists: Design, Synthesis & Biological Evaluation

Based on a known pharmacophore model for 5-HT(6) receptor antagonists, a series of novel extended derivatives of the N-arylsulfonyindole scaffold were designed and identified as a new class of 5-HT(6) receptor modulators. Eight of the compounds exhibited moderate to high binding affinities and displ...

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Detalles Bibliográficos
Autores principales: Vera, Gonzalo, Lagos, Carlos F., Almendras, Sebastián, Hebel, Dan, Flores, Francisco, Valle-Corvalán, Gissella, Pessoa-Mahana, C. David, Mella-Raipán, Jaime, Montecinos, Rodrigo, Recabarren-Gajardo, Gonzalo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273627/
https://www.ncbi.nlm.nih.gov/pubmed/27537868
http://dx.doi.org/10.3390/molecules21081070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273627/
https://www.ncbi.nlm.nih.gov/pubmed/27537868
http://dx.doi.org/10.3390/molecules21081070

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