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Extended N-Arylsulfonylindoles as 5-HT(6) Receptor Antagonists: Design, Synthesis & Biological Evaluation
Based on a known pharmacophore model for 5-HT(6) receptor antagonists, a series of novel extended derivatives of the N-arylsulfonyindole scaffold were designed and identified as a new class of 5-HT(6) receptor modulators. Eight of the compounds exhibited moderate to high binding affinities and displ...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273627/ https://www.ncbi.nlm.nih.gov/pubmed/27537868 http://dx.doi.org/10.3390/molecules21081070 |