Design and Synthesis of Vandetanib Derivatives Containing Nitroimidazole Groups as Tyrosine Kinase Inhibitors in Normoxia and Hypoxia

Sixteen novel epidermal growth factor receptor (EGFR)/vascular endothelial growth factor (VEGF)-2 inhibitors (nitroimidazole-substituted 4-anilinoquinazoline derivatives (16a–p)) were designed and prepared via the introduction of a nitroimidazole group in the piperidine side chain and modification o...

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Detalles Bibliográficos
Autores principales: Wei, Huiqiang, Li, Deguan, Yang, Xiangbo, Shang, Haihua, Fan, Saijun, Li, Yiliang, Song, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273768/
https://www.ncbi.nlm.nih.gov/pubmed/27983649
http://dx.doi.org/10.3390/molecules21121693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273768/
https://www.ncbi.nlm.nih.gov/pubmed/27983649
http://dx.doi.org/10.3390/molecules21121693

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