Identification of the Structural Features of Guanine Derivatives as MGMT Inhibitors Using 3D-QSAR Modeling Combined with Molecular Docking

DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT), which plays an important role in inducing drug resistance against alkylating agents that modify the O(6) position of guanine in DNA, is an attractive target for anti-tumor chemotherapy. A series of MGMT inhibitors have been synthesiz...

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Detalles Bibliográficos
Autores principales: Sun, Guohui, Fan, Tengjiao, Zhang, Na, Ren, Ting, Zhao, Lijiao, Zhong, Rugang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273773/
https://www.ncbi.nlm.nih.gov/pubmed/27347909
http://dx.doi.org/10.3390/molecules21070823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273773/
https://www.ncbi.nlm.nih.gov/pubmed/27347909
http://dx.doi.org/10.3390/molecules21070823

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