Synthesis of Canthardin Sulfanilamides and Their Acid Anhydride Analogues via a Ring-Opening Reaction of Activated Aziridines and Their Associated Pharmacological Effects

The cantharidinimide derivatives, 5a–h, including sulfanilamides containing pyrimidyl, pyrazinyl, hydrogen, thiazolyl, and oxazolyl groups were synthesized. Modification of cantharidinimide by means of the reaction of activated aziridine ring opening led to the discovery of a novel class of antitumo...

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Detalles Bibliográficos
Autores principales: Chiang, Ling-Ling, Tseng, Ing-Jy, Lin, Pen-Yuan, Sheu, Shiow-Yunn, Lin, Ching-Tung, Hsieh, Yun-Han, Lin, Yi-Jing, Chen, Hsiao-Ling, Lin, Mei-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273973/
https://www.ncbi.nlm.nih.gov/pubmed/26784163
http://dx.doi.org/10.3390/molecules21010100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273973/
https://www.ncbi.nlm.nih.gov/pubmed/26784163
http://dx.doi.org/10.3390/molecules21010100

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