Cargando…

Synthesis and Pharmacological Evaluation of Novel Pleuromutilin Derivatives with Substituted Benzimidazole Moieties

A series of novel pleuromutilin derivatives with substituted benzimidazole moieties were designed and synthesized from pleuromutilin and 5-amino-2-mercaptobenzimidazole through sequential reactions. All the newly synthesized compounds were characterized by IR, NMR, and HRMS. Each of the derivatives...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ai, Xin, Pu, Xiuying, Yi, Yunpeng, Liu, Yu, Xu, Shuijin, Liang, Jianping, Shang, Ruofeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273978/ https://www.ncbi.nlm.nih.gov/pubmed/27834819 http://dx.doi.org/10.3390/molecules21111488

Ejemplares similares

Chemical Synthesis and Biological Activities of Novel Pleuromutilin Derivatives with Substituted Amino Moiety
por: Shang, Ruofeng, et al.
Publicado: (2013)

Synthesis and Biological Activity Evaluation of Novel Heterocyclic Pleuromutilin Derivatives
por: Yi, Yunpeng, et al.
Publicado: (2017)

Synthesis and Biological Evaluation of New Pleuromutilin Derivatives as Antibacterial Agents
por: Shang, Ruo-Feng, et al.
Publicado: (2014)

Design, synthesis, biological evaluation and molecular docking study of novel pleuromutilin derivatives containing substituted benzoxazole as antibacterial agents
por: Ren, Jie, et al.
Publicado: (2023)

Synthesis, biological activities and docking studies of pleuromutilin derivatives with piperazinyl urea linkage
por: Zhang, Yuanyuan, et al.
Publicado: (2021)

Synthesis and biological profile of substituted benzimidazoles
por: Vashist, Neelam, et al.
Publicado: (2018)

Synthesis and cytotoxic evaluation of novel quinozalinone derivatives with substituted benzimidazole in position 3
por: Taherian, Elham, et al.
Publicado: (2019)

Preliminary SAR of Novel Pleuromutilin–Polyamine Conjugates
por: Sue, Kenneth, et al.
Publicado: (2023)

Synthesis and antibacterial activity of novel levofloxacin derivatives containing a substituted thienylethyl moiety
por: Mohammadhosseini, Negar, et al.
Publicado: (2012)

Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups
por: Wang, Qi, et al.
Publicado: (2022)

Discovery of Novel Pleuromutilin Derivatives as Potent Antibacterial Agents for the Treatment of MRSA Infection
por: Fang, Han-Qing, et al.
Publicado: (2022)

Synthesis, characterization and in vitro, in vivo, in silico biological evaluations of substituted benzimidazole derivatives
por: Raka, Sabreena Chowdhury, et al.
Publicado: (2022)

Design, synthesis, biological evaluation and QSAR analysis of novel N-substituted benzimidazole derived carboxamides
por: Beč, Anja, et al.
Publicado: (2022)

Collateral sensitivity to pleuromutilins in vancomycin-resistant Enterococcus faecium
por: Li, Qian, et al.
Publicado: (2022)

Design and synthesis of amino acid derivatives of substituted benzimidazoles and pyrazoles as Sirt1 inhibitors
por: Purushotham, Nikil, et al.
Publicado: (2022)

Synthesis, Characterization and Biological Investigations of Half-Sandwich Ruthenium(II) Complexes Containing Benzimidazole Moiety
por: Rogala, Patrycja, et al.
Publicado: (2022)

Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation
por: Beč, Anja, et al.
Publicado: (2023)

Synthesis and Properties of Poly(imides) and Poly(imides)/Ionic Liquid Composites Bearing a Benzimidazole Moiety
por: Terraza, Claudio A., et al.
Publicado: (2019)

Synthesis and Biological Evaluation of 3-Substituted-indolin-2-one Derivatives Containing Chloropyrrole Moieties
por: Jin, Yun-Zhou, et al.
Publicado: (2011)

Synthesis and potential antimicrobial activity of novel α-aminophosphonates derivatives bearing substituted quinoline or quinolone and thiazole moieties
por: Litim, Bilal, et al.
Publicado: (2021)

Assessing Boron-Pleuromutilin AN11251 for the Development of Antibacterial Agents
por: Han, Ming-Jie, et al.
Publicado: (2023)

Recent achievements in the synthesis of benzimidazole derivatives
por: Chung, Nguyen Thi, et al.
Publicado: (2023)

Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives
por: Alberti, Fabrizio, et al.
Publicado: (2017)

Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives
por: Keng Yoon, Yeong, et al.
Publicado: (2013)

Synthesis, in Vitro Antimycobacterial and Antibacterial Evaluation of IMB-070593 Derivatives Containing a Substituted Benzyloxime Moiety
por: Wei, Zengquan, et al.
Publicado: (2013)

Synthesis and Biological Activity of Substituted Urea and Thiourea Derivatives Containing 1,2,4-Triazole Moieties
por: Kocyigit-Kaymakcioglu, Bedia, et al.
Publicado: (2013)

Nucleophilic and electrophilic cyclization of N-alkyne-substituted pyrrole derivatives: Synthesis of pyrrolopyrazinone, pyrrolotriazinone, and pyrrolooxazinone moieties
por: Yenice, Işıl, et al.
Publicado: (2017)

Synthesis, Antiproliferative Evaluation and QSAR Analysis of Novel Halogen- and Amidino-Substituted Benzothiazoles and Benzimidazoles
por: Rep Kaulić, Valentina, et al.
Publicado: (2022)

The Very First Modification of Pleuromutilin and Lefamulin by Photoinitiated Radical Addition Reactions—Synthesis and Antibacterial Studies
por: Thai Le, Son, et al.
Publicado: (2021)

Design, Synthesis and Bioactivities of Novel 1,4-Pentadien-3-one Derivatives Containing a Substituted Pyrazolyl Moiety
por: Chen, Cuili, et al.
Publicado: (2017)

Multi PCET in symmetrically substituted benzimidazoles
por: Odella, Emmanuel, et al.
Publicado: (2021)

Syntheses of Nickel (II) Complexes from Novel Semicarbazone Ligands with Chloroformylarylhydrazine, Benzimidazole and Salicylaldehyde Moieties
por: Shih, Mei-Hsiu, et al.
Publicado: (2015)

Novel Benzothiazole, Benzimidazole and Benzoxazole Derivatives as Potential Antitumor Agents: Synthesis and Preliminary in Vitro Biological Evaluation
por: Xiang, Pu, et al.
Publicado: (2012)

Synthesis of the Isodityrosine Moiety of Seongsanamide A–D and Its Derivatives
por: Xie, Yang, et al.
Publicado: (2023)

Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
por: Can, Nafiz Öncü, et al.
Publicado: (2017)

Insights into the Classical Genetics of Clitopilus passeckerianus – the Pleuromutilin Producing Mushroom
por: de Mattos-Shipley, Kate M. J., et al.
Publicado: (2017)

Biosynthesis of pleuromutilin congeners using an Aspergillus oryzae expression platform
por: Alberti, Fabrizio, et al.
Publicado: (2023)

A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism
por: Eyal, Zohar, et al.
Publicado: (2016)

Synthesis of Benzimidazole-Sulfonyl Derivatives and Their Biological Activities
por: Mulugeta, Endale, et al.
Publicado: (2022)

Pyrimido[1,2-a]benzimidazoles: synthesis and perspective of their pharmacological use
por: Fedotov, Victor V., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0jlsj9m7hhqn5v96f7batvm69q