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Capsaicin: From Plants to a Cancer-Suppressing Agent
Capsaicinoids are plant secondary metabolites, capsaicin being the principal responsible for the pungency of chili peppers. It is biosynthesized through two pathways involved in phenylpropanoid and fatty acid metabolism. Plant capsaicin concentration is mainly affected by genetic, environmental and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274000/ https://www.ncbi.nlm.nih.gov/pubmed/27472308 http://dx.doi.org/10.3390/molecules21080931 |
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author | Chapa-Oliver, Angela M. Mejía-Teniente, Laura |
author_facet | Chapa-Oliver, Angela M. Mejía-Teniente, Laura |
author_sort | Chapa-Oliver, Angela M. |
collection | PubMed |
description | Capsaicinoids are plant secondary metabolites, capsaicin being the principal responsible for the pungency of chili peppers. It is biosynthesized through two pathways involved in phenylpropanoid and fatty acid metabolism. Plant capsaicin concentration is mainly affected by genetic, environmental and crop management factors. However, its synthesis can be enhanced by the use of elicitors. Capsaicin is employed as food additive and in pharmaceutical applications. Additionally, it has been found that capsaicin can act as a cancer preventive agent and shows wide applications against various types of cancer. This review is an approach in contextualizing the use of controlled stress on the plant to increase the content of capsaicin, highlighting its synthesis and its potential use as anticancer agent. |
format | Online Article Text |
id | pubmed-6274000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62740002018-12-28 Capsaicin: From Plants to a Cancer-Suppressing Agent Chapa-Oliver, Angela M. Mejía-Teniente, Laura Molecules Review Capsaicinoids are plant secondary metabolites, capsaicin being the principal responsible for the pungency of chili peppers. It is biosynthesized through two pathways involved in phenylpropanoid and fatty acid metabolism. Plant capsaicin concentration is mainly affected by genetic, environmental and crop management factors. However, its synthesis can be enhanced by the use of elicitors. Capsaicin is employed as food additive and in pharmaceutical applications. Additionally, it has been found that capsaicin can act as a cancer preventive agent and shows wide applications against various types of cancer. This review is an approach in contextualizing the use of controlled stress on the plant to increase the content of capsaicin, highlighting its synthesis and its potential use as anticancer agent. MDPI 2016-07-27 /pmc/articles/PMC6274000/ /pubmed/27472308 http://dx.doi.org/10.3390/molecules21080931 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chapa-Oliver, Angela M. Mejía-Teniente, Laura Capsaicin: From Plants to a Cancer-Suppressing Agent |
title | Capsaicin: From Plants to a Cancer-Suppressing Agent |
title_full | Capsaicin: From Plants to a Cancer-Suppressing Agent |
title_fullStr | Capsaicin: From Plants to a Cancer-Suppressing Agent |
title_full_unstemmed | Capsaicin: From Plants to a Cancer-Suppressing Agent |
title_short | Capsaicin: From Plants to a Cancer-Suppressing Agent |
title_sort | capsaicin: from plants to a cancer-suppressing agent |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274000/ https://www.ncbi.nlm.nih.gov/pubmed/27472308 http://dx.doi.org/10.3390/molecules21080931 |
work_keys_str_mv | AT chapaoliverangelam capsaicinfromplantstoacancersuppressingagent AT mejiatenientelaura capsaicinfromplantstoacancersuppressingagent |