Protocatechualdehyde Induces S-Phase Arrest and Apoptosis by Stimulating the p27(KIP1)-Cyclin A/D1-CDK2 and Mitochondrial Apoptotic Pathways in HT-29 Cells

Protocatechualdehyde (PCA) extracted from Phellinus gilvus exhibits anti-cancer activity in human colorectal carcinoma cells (HT-29). However, the underlying mechanisms remain poorly understood. We performed an in vitro study involving MTT, flow cytometry, RT-PCR, and western blot analyses to invest...

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Detalles Bibliográficos
Autores principales: Zhong, Shi, Li, You-Gui, Ji, Dong-Feng, Lin, Tian-Bao, Lv, Zhi-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274009/
https://www.ncbi.nlm.nih.gov/pubmed/27447597
http://dx.doi.org/10.3390/molecules21070934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274009/
https://www.ncbi.nlm.nih.gov/pubmed/27447597
http://dx.doi.org/10.3390/molecules21070934

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