Antiproliferative Fate of the Tetraploid Formed after Mitotic Slippage and Its Promotion; A Novel Target for Cancer Therapy Based on Microtubule Poisons

Microtubule poisons inhibit spindle function, leading to activation of spindle assembly checkpoint (SAC) and mitotic arrest. Cell death occurring in prolonged mitosis is the first target of microtubule poisons in cancer therapies. However, even in the presence of microtubule poisons, SAC and mitotic...

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Detalles Bibliográficos
Autores principales: Nakayama, Yuji, Inoue, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274067/
https://www.ncbi.nlm.nih.gov/pubmed/27213315
http://dx.doi.org/10.3390/molecules21050663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274067/
https://www.ncbi.nlm.nih.gov/pubmed/27213315
http://dx.doi.org/10.3390/molecules21050663

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