Glutamine Synthetase Drugability beyond Its Active Site: Exploring Oligomerization Interfaces and Pockets

Background: Glutamine synthetase (GS) is a crucial enzyme to the nitrogen cycle with great commercial and pharmaceutical value. Current inhibitors target the active site, affecting GS activity indiscriminately in all organisms. As the active site is located at the interface between two monomers, the...

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Detalles Bibliográficos
Autores principales: Moreira, Cátia, Ramos, Maria J., Fernandes, Pedro A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274088/
https://www.ncbi.nlm.nih.gov/pubmed/27509490
http://dx.doi.org/10.3390/molecules21081028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274088/
https://www.ncbi.nlm.nih.gov/pubmed/27509490
http://dx.doi.org/10.3390/molecules21081028

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