Cargando…

Evaluation and Comparison of the Inhibition Effect of Astragaloside IV and Aglycone Cycloastragenol on Various UDP-Glucuronosyltransferase (UGT) Isoforms

As one of the main active ingredients from Radix Astragali (RA), orally dosed astragaloside IV (AST) is easily transformed to sapogenin-cycloastragenol (CAG) by deglycosylation in the gastrointestinal tract. Because the potential adverse effects of AST and CAG remain unclear, the present study in th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ran, Ruixue, Zhang, Chunze, Li, Rongshan, Chen, Bowei, Zhang, Weihua, Zhao, Zhenying, Fu, Zhiwei, Du, Zuo, Du, Xiaolang, Yang, Xiaolong, Fang, Zhongze
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274106/ https://www.ncbi.nlm.nih.gov/pubmed/27916843 http://dx.doi.org/10.3390/molecules21121616

Ejemplares similares

In Vitro Comparative Study of the Inhibitory Effects of Mangiferin and Its Aglycone Norathyriol towards UDP-Glucuronosyl Transferase (UGT) Isoforms
por: Sun, Dan, et al.
Publicado: (2017)

Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs)
por: Zhang, Xu-Xin, et al.
Publicado: (2017)

Inhibitory Effect of Sauchinone on UDP-Glucuronosyltransferase (UGT) 2B7 Activity
por: You, Byoung Hoon, et al.
Publicado: (2018)

Inhibition of UDP‐glucuronosyltransferase by Aglycons of Natural Glucuronides in Kampo Medicines Using SN‐38 as a Substrate
por: Yokoi, Tsuyoshi, et al.
Publicado: (1995)

The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis
por: Duthaler, Urs, et al.
Publicado: (2023)

Truncated UDP-glucuronosyltransferase (UGT) from a Crigler–Najjar syndrome type II patient colocalizes with intact UGT in the endoplasmic reticulum
por: Suzuki, Masahiro, et al.
Publicado: (2014)

Interception of Benzo[a]pyrene-7,8-dione by UDP Glucuronosyltransferases (UGTs) in Human Lung Cells
por: Zhang, Li, et al.
Publicado: (2013)

Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia
por: Aoshima, Naoya, et al.
Publicado: (2014)

Inhibitory effects of UDP-glucuronosyltransferase (UGT) typical ligands against E. coli beta-glucuronidase (GUS)
por: Xiao, Ling, et al.
Publicado: (2020)

The evolution of UDP-glycosyl/glucuronosyltransferase 1E (UGT1E) genes in bird lineages is linked to feeding habits but UGT2 genes is not
por: Kawai, Yusuke K., et al.
Publicado: (2018)

Effect of UDP-Glucuronosyltransferase (UGT) 1A Polymorphism (rs8330 and rs10929303) on Glucuronidation Status of Acetaminophen
por: Mehboob, Huma, et al.
Publicado: (2017)

Demethylzeylasteral Exhibits Strong Inhibition towards UDP-Glucuronosyltransferase (UGT) 1A6 and 2B7
por: Zhao, Jin-Wen, et al.
Publicado: (2012)

Inter-isoform Hetero-dimerization of Human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A9, and 2B7 and Impacts on Glucuronidation Activity
por: Yuan, Ling-Min, et al.
Publicado: (2016)

Functional characterization of a cycloartenol synthase and four glycosyltransferases in the biosynthesis of cycloastragenol-type astragalosides from Astragalus membranaceus
por: Duan, Yangyang, et al.
Publicado: (2023)

Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action
por: Sarfstein, Rive, et al.
Publicado: (2022)

Cycloastragenol and Astragaloside IV activate telomerase and protect nucleus pulposus cells against high glucose-induced senescence and apoptosis
por: Hong, Haofeng, et al.
Publicado: (2021)

Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors
por: Kasteel, E. E. J., et al.
Publicado: (2020)

Regulation of Sulfotransferase and UDP-Glucuronosyltransferase Gene Expression by the PPARs
por: Runge-Morris, Melissa, et al.
Publicado: (2009)

Structure and Protein–Protein Interactions of Human UDP-Glucuronosyltransferases
por: Fujiwara, Ryoichi, et al.
Publicado: (2016)

UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression
por: Grant, Delores J., et al.
Publicado: (2017)

Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues
por: Zhou, Lucas, et al.
Publicado: (2023)

Identification of Human UDP-Glucuronosyltransferase Involved in Gypensapogenin C Glucuronidation and Species Differences
por: Chen, Juan, et al.
Publicado: (2023)

UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?
por: Stücker, I, et al.
Publicado: (2007)

Characterization of UDP-glucuronosyltransferase (UGT1A1) Promoter Polymorphisms and Gene Expression on Ethnicity, Stage of Disease, and Menopausal Status in Breast Cancer
por: Starlard-Davenport, Athena, et al.
Publicado: (2012)

Contributions of UDP-Glucuronosyltransferases to Human Hepatic and Intestinal Metabolism of Ticagrelor and Inhibition of UGTs and Cytochrome P450 Enzymes by Ticagrelor and its Glucuronidated Metabolite
por: Liu, Shuaibing, et al.
Publicado: (2021)

Effects of Dietary Components on Testosterone Metabolism via UDP-Glucuronosyltransferase
por: Jenkinson, Carl, et al.
Publicado: (2013)

The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase
por: Jiang, Li-Peng, et al.
Publicado: (2014)

Comparison of the Inhibitory Potential of Bavachalcone and Corylin against UDP-Glucuronosyltransferases
por: Shan, Lina, et al.
Publicado: (2014)

Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression
por: Allain, Eric P., et al.
Publicado: (2020)

Dysregulated hepatic UDP-glucuronosyltransferases and flavonoids glucuronidation in experimental colitis
por: Zeng, Wanying, et al.
Publicado: (2022)

Molecular Mechanism of the UDP-Glucuronosyltransferase 2B20-like Gene (AccUGT2B20-like) in Pesticide Resistance of Apis cerana cerana
por: Cui, Xuepei, et al.
Publicado: (2020)

Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR
por: Yang, Xiaojing, et al.
Publicado: (2023)

Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview
por: Guillemette, Chantal, et al.
Publicado: (2004)

Expression of UDP-glucuronosyltransferase 1A4 in human placenta at term
por: Reimers, Arne, et al.
Publicado: (2010)

The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication
por: Ouzzine, Mohamed, et al.
Publicado: (2014)

Fluid intake, genetic variants of UDP-glucuronosyltransferases, and bladder cancer risk
por: Wang, J, et al.
Publicado: (2013)

Endogenous Protein Interactome of Human UDP-Glucuronosyltransferases Exposed by Untargeted Proteomics
por: Rouleau, Michèle, et al.
Publicado: (2017)

Age-Dependent Hepatic UDP-Glucuronosyltransferase Gene Expression and Activity in Children
por: Neumann, Elizabeth, et al.
Publicado: (2016)

Thiamethoxam Resistance in Aphis gossypii Glover Relies on Multiple UDP-Glucuronosyltransferases
por: Pan, Yiou, et al.
Publicado: (2018)

Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice
por: Böhmdorfer, Michaela, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_cen4ukau11g9abt8hkq8mgbu4g