Enhanced Cellular Uptake and Pharmacokinetic Characteristics of Doxorubicin-Valine Amide Prodrug

In this study, we synthesized the valine (Val)-conjugated amide prodrug of doxorubicin (DOX) by the formation of amide bonds between DOX and Val. The synthesis of the DOX-Val prodrug was identified by a proton nuclear magnetic resonance ((1)H-NMR) assay. In the MCF-7 cells (human breast adenocarcino...

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Detalles Bibliográficos
Autores principales: Park, Yohan, Park, Ju-Hwan, Park, Suryeon, Lee, Song Yi, Cho, Kwan Hyung, Kim, Dae-Duk, Shim, Won-Sik, Yoon, In-Soo, Cho, Hyun-Jong, Maeng, Han-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274118/
https://www.ncbi.nlm.nih.gov/pubmed/27669201
http://dx.doi.org/10.3390/molecules21101272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274118/
https://www.ncbi.nlm.nih.gov/pubmed/27669201
http://dx.doi.org/10.3390/molecules21101272

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