An Ingenol Derived from Euphorbia kansui Induces Hepatocyte Cytotoxicity by Triggering G0/G1 Cell Cycle Arrest and Regulating the Mitochondrial Apoptosis Pathway in Vitro

Natural product lingenol, a purified diterpenoid compound derived from the root of Euphorbia kansui, exerts serious hepatotoxicity; however, the molecular mechanisms remain to be defined. In the present study, cell counting Kit-8 (CCK-8), inverted phase contrast microscope and flow cytometry were us...

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Detalles Bibliográficos
Autores principales: Yan, Xiaojing, Zhang, Li, Cao, Yudan, Yao, Weifeng, Tang, Yuping, Ding, Anwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274136/
https://www.ncbi.nlm.nih.gov/pubmed/27338329
http://dx.doi.org/10.3390/molecules21060813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274136/
https://www.ncbi.nlm.nih.gov/pubmed/27338329
http://dx.doi.org/10.3390/molecules21060813

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