Investigating Glycol-Split-Heparin-Derived Inhibitors of Heparanase: A Study of Synthetic Trisaccharides

Heparanase is the only known endoglycosidase able to cleave heparan sulfate. Roneparstat and necuparanib, heparanase inhibitors obtained from heparin and currently being tested in man as a potential drugs against cancer, contain in their structure glycol-split uronic acid moieties probably responsib...

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Detalles Bibliográficos
Autores principales: Ni, Minghong, Elli, Stefano, Naggi, Annamaria, Guerrini, Marco, Torri, Giangiacomo, Petitou, Maurice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274180/
https://www.ncbi.nlm.nih.gov/pubmed/27886097
http://dx.doi.org/10.3390/molecules21111602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274180/
https://www.ncbi.nlm.nih.gov/pubmed/27886097
http://dx.doi.org/10.3390/molecules21111602

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