Cargando…

In Vitro Neuroprotective and Anti-Inflammatory Activities of Natural and Semi-Synthetic Spirosteroid Analogues

Two spirosteroid analogues were synthesized and evaluated for their in vitro neuroprotective activities in PC12 cells, against glutamate-induced excitotoxicity and mitochondrial damage in glucose deprivation conditions, as well as their anti-inflammatory potential in LPS/IFNγ-stimulated microglia pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	García-Pupo, Laura, Zaldo-Castro, Armando, Exarchou, Vassiliki, Tacoronte-Morales, Juan Enrique, Pieters, Luc, Vanden Berghe, Wim, Nuñez-Figueredo, Yanier, Delgado-Hernández, René
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274191/ https://www.ncbi.nlm.nih.gov/pubmed/27483221 http://dx.doi.org/10.3390/molecules21080992

Ejemplares similares

Diversity-oriented synthesis of 17-spirosteroids
por: Laroche, Benjamin, et al.
Publicado: (2020)

Emerging immune and cell death mechanisms in stroke: Saponins as therapeutic candidates
por: García-Pupo, Laura, et al.
Publicado: (2020)

Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex Exudate
por: Amin, Adnan, et al.
Publicado: (2016)

A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence
por: Skidmore, Mark A., et al.
Publicado: (2017)

Inhibition of the NF-κB Signaling Pathway by a Novel Heterocyclic Curcumin Analogue
por: Katsori, Anna-Maria, et al.
Publicado: (2015)

In Vitro and In Silico Antidiabetic and Antimicrobial Evaluation of Constituents from Kickxia ramosissima (Nanorrhinum ramosissimum)
por: Amin, Adnan, et al.
Publicado: (2017)

Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents
por: Zhang, Yun-Kai, et al.
Publicado: (2015)

In Vitro Biotransformation and Anti-Inflammatory Activity of Constituents and Metabolites of Filipendula ulmaria
por: Van der Auwera, Anastasia, et al.
Publicado: (2023)

Antioxidant and Antiglycating Constituents from Leaves of Ziziphus oxyphylla and Cedrela serrata
por: Ahmad, Rizwan, et al.
Publicado: (2016)

Treatment with Rhus tripartita extract curtails isoproterenol-elicited cardiotoxicity and oxidative stress in rats
por: Shahat, Abdelaaty A., et al.
Publicado: (2016)

Autophagy-dependent apoptosis is triggered by a semi-synthetic [6]-gingerol analogue in triple negative breast cancer cells
por: Luna-Dulcey, Liany, et al.
Publicado: (2018)

Semi-synthetic cinnamodial analogues: Structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito Aedes aegypti
por: Manwill, Preston K., et al.
Publicado: (2020)

Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer
por: Abacha, Yabalu Z., et al.
Publicado: (2022)

Synthetic Analogue of Butenolide as an Antifouling Agent
por: Chiang, Ho Yin, et al.
Publicado: (2021)

In Vitro Anti-Inflammatory, Anti-Oxidant, and Cytotoxic Activities of Four Curcuma Species and the Isolation of Compounds from Curcuma aromatica Rhizome
por: Pintatum, Aknarin, et al.
Publicado: (2020)

Tackling Chronic Inflammation with Withanolide Phytochemicals—A Withaferin A Perspective
por: Logie, Emilie, et al.
Publicado: (2020)

Characterization of Blood Surrogate Immune-Methylation Biomarkers for Immune Cell Infiltration in Chronic Inflammaging Disorders
por: Declerck, Ken, et al.
Publicado: (2019)

Synthetic and semi-synthetic strategies to study ubiquitin signaling
por: van Tilburg, Gabriëlle BA, et al.
Publicado: (2016)

Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism
por: D’Incal, Claudio Peter, et al.
Publicado: (2023)

Bioluminescent Properties of Semi-Synthetic Obelin and Aequorin Activated by Coelenterazine Analogues with Modifications of C-2, C-6, and C-8 Substituents
por: Eremeeva, Elena V., et al.
Publicado: (2020)

Synthetic and semi-synthetic approaches to unprotected N-glycan oxazolines
por: Fairbanks, Antony J
Publicado: (2018)

Synthesis and biological evaluation of capsaicin analogues as antioxidant and neuroprotective agents
por: Xie, Mao, et al.
Publicado: (2023)

Contextual Factors Affecting the Use and Acquisition of Affirmative Operators: A Methodological-Didactic Tool Based on Spanish
por: Laurencio Tacoronte, Ariel
Publicado: (2022)

Analogue, Digital and Semi-Digital Energy Reconstruction in the CALICE AHCAL
por: Neubüser, C, et al.
Publicado: (2014)

Analogue, Digital and Semi-Digital Energy Reconstruction in the CALICE AHCAL
por: CALICE Collaboration
Publicado: (2014)

Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands
por: Zampieri, Daniele, et al.
Publicado: (2023)

A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate
por: Riley, Andrew M., et al.
Publicado: (2018)

Synthetic mRNAs; Their Analogue Caps and Contribution to Disease
por: Kyriakopoulos, Anthony M., et al.
Publicado: (2021)

Ebselen and Analogues: Pharmacological Properties and Synthetic Strategies for Their Preparation
por: Santi, Claudio, et al.
Publicado: (2021)

Synthetic Methods for the Preparation of Conformationally Restricted Analogues of Nicotine
por: Panda, Biswajit, et al.
Publicado: (2021)

An investigation of the antileishmanial properties of semi-synthetic saponins
por: Anderson, Orlagh, et al.
Publicado: (2020)

Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A
por: Morais, Thiago R., et al.
Publicado: (2020)

SCT - Semi-Conductor Tracker
por: Vanden Broeck, Renilde
Publicado: (2019)

Plants and Natural Products with Activity against Various Types of Coronaviruses: A Review with Focus on SARS-CoV-2
por: Llivisaca-Contreras, Susana A., et al.
Publicado: (2021)

Caspases leave the beaten track: caspase-mediated activation of NF-κB
por: Lamkanfi, Mohamed, et al.
Publicado: (2006)

Mining the human proteome for conserved mechanisms
por: Naulaerts, Stefan, et al.
Publicado: (2015)

International mobility, sexual behaviour and HIV-related characteristics of men who have sex with men residing in Belgium
por: Vanden Berghe, Wim, et al.
Publicado: (2013)

Antimicrobial Activity of the Marine Alkaloids, Clathrodin and Oroidin, and Their Synthetic Analogues
por: Zidar, Nace, et al.
Publicado: (2014)

Synthetic surfactin analogues have improved anti-PEDV properties
por: Yuan, Lvfeng, et al.
Publicado: (2019)

Special Issue: From Natural Polyphenols to Synthetic Bioactive Analogues
por: Tringali, Corrado
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v6vq42h6n5fqbnpbkghgdm2opv