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Regioselective Palmitoylation of 9-(2,3-Dihydroxy- propyl)adenine Catalyzed by a Glycopolymer-enzyme Conjugate

The enzymatic regioselective monopalmitoylation of racemic 9-(2,3-dihydroxypropyl)- adenine (DHPA), an approved antiviral agent, has been performed by an immobilized form of Candida antarctica B lipase (CAL-B) using a 4:1 DMF/hexane mixture as the reaction medium. To improve the chemical yield of th...

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Detalles Bibliográficos
Autores principales: Brabcová, Jana, Blažek, Jiří, Krečmerová, Marcela, Vondrášek, Jiří, Palomo, Jose M., Zarevúcka, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274252/
https://www.ncbi.nlm.nih.gov/pubmed/27196879
http://dx.doi.org/10.3390/molecules21050648