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Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives

Twenty-two 7-fluoro (or 8-methoxy)-4-anilinoquinolines compounds were designed and synthesized as potentially potent and selective antitumor inhibitors. All the prepared compounds were evaluated for their in vitro antiproliferative activities against the HeLa and BGC823 cell lines. Ten compounds (1a...

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Detalles Bibliográficos
Autores principales: Liu, Dan, Luan, Tian, Kong, Jian, Zhang, Ying, Wang, Hai-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274288/
https://www.ncbi.nlm.nih.gov/pubmed/26703559
http://dx.doi.org/10.3390/molecules21010021
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author Liu, Dan
Luan, Tian
Kong, Jian
Zhang, Ying
Wang, Hai-Feng
author_facet Liu, Dan
Luan, Tian
Kong, Jian
Zhang, Ying
Wang, Hai-Feng
author_sort Liu, Dan
collection PubMed
description Twenty-two 7-fluoro (or 8-methoxy)-4-anilinoquinolines compounds were designed and synthesized as potentially potent and selective antitumor inhibitors. All the prepared compounds were evaluated for their in vitro antiproliferative activities against the HeLa and BGC823 cell lines. Ten compounds (1a–g; 2c; 2e and 2i) exhibited excellent antitumor activity superior to that of gefitinib. Among the ten compounds; seven (1a–c; 1e–1g and 2i) displayed excellent selectivity for BGC823 cells. In particular; 1f and 2i exhibited potent cytotoxic activities against HeLa cells and BGC823 cells with better IC(50) values than gefitinib.
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spelling pubmed-62742882018-12-28 Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives Liu, Dan Luan, Tian Kong, Jian Zhang, Ying Wang, Hai-Feng Molecules Article Twenty-two 7-fluoro (or 8-methoxy)-4-anilinoquinolines compounds were designed and synthesized as potentially potent and selective antitumor inhibitors. All the prepared compounds were evaluated for their in vitro antiproliferative activities against the HeLa and BGC823 cell lines. Ten compounds (1a–g; 2c; 2e and 2i) exhibited excellent antitumor activity superior to that of gefitinib. Among the ten compounds; seven (1a–c; 1e–1g and 2i) displayed excellent selectivity for BGC823 cells. In particular; 1f and 2i exhibited potent cytotoxic activities against HeLa cells and BGC823 cells with better IC(50) values than gefitinib. MDPI 2015-12-23 /pmc/articles/PMC6274288/ /pubmed/26703559 http://dx.doi.org/10.3390/molecules21010021 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Dan
Luan, Tian
Kong, Jian
Zhang, Ying
Wang, Hai-Feng
Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives
title Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives
title_full Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives
title_fullStr Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives
title_full_unstemmed Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives
title_short Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives
title_sort synthesis and anti-tumor activities of 4-anilinoquinoline derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274288/
https://www.ncbi.nlm.nih.gov/pubmed/26703559
http://dx.doi.org/10.3390/molecules21010021
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